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vs   Topical HA

HA in creams, lotions and serums will be unable to reach the dermis to increase levels of HA in the skin. This is because HA has a large molecular size and cannot penetrate the skin’s surface. Oral intakes of HA will be more effective as the molecule does not need to penetrate the epidermis and will be absorbed and distributed to the dermis via blood vessels.

vs  injectable HA

Injected HA needs to be chemically transformed (cross-linked) in order to stay in the skin. This type of modification affects the natural biological properties of the HA molecule (lower water-binding capacity, lower production of extracellular matrix components) (1) and the injected HA will act mechanically as an implant for a visible action only in the zone where it has been injected. Orally administered HA will not be transformed and will act naturally to increase the water content and the endogenous HA levels in all the skin regions. Also, orally administered HA will avoid the office visits, the patient inconvenience, the adverse events and the risk associated with injections.

vs  oral collagen

Collagen is only from animal origin whereas the HA in Rheoderm is from non-animal origin. The purity of HA is higher than that of collagen and collagen can produce allergic reactions whereas HA is completely non-allergenic.

Unlike collagen, HA is free from animal proteins and from possible transmissible infectious agents (viruses and prions). Finally, clinical studies showed that oral collagen was less effective than oral HA to increase skin hydration and elasticity and to reduce wrinkles (2)


1. A. Tezel, G. H. Fredrickson. The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy. 2008 Mar;10(1):35-42. 

2. Ingestion of an oral Hyaluronan solution improves skin hydration, wrinkle reduction, elasticity, and skin roughness: results of a clinical study. J Evid Based Complementary Altern Med. 2017 Oct;22(4):816-823. 

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