Boost your NAD+ levels

What is Rheoderm® NMN ?

Rheoderm® NMN is a nicotinamide mononucleotide and hyaluronic acid supplement designed to boost NAD+ levels and support cellular repair and protection, helping reduce the signs of skin aging.

Rheoderm® NMN is composed of pharmaceutical-grade nicotinamide mononucleotide and hyaluronic acid obtained through biofermentation.

What is hyaluronic acid ?

An essential molecule whose quantity decreases with age

Hyaluronic acid (HA), a major component of the skin, is fundamental to retain water and maintain healthy skin tone, elasticity, and a smooth, youthful appearance (1).

However, aging and extrinsic stimuli such as solar ultraviolet radiation, smoking, and air pollutants gradually reduces the amount of HA in the skin (2-5).

The skin loses elasticity and firmness, becomes thinner and dry, and fine lines appear on its surface. Therefore, correcting this loss of HA is an essential component of an anti-aging strategy.

A large molecule whose skin penetration is problematic

​As the molecular weight of HA is relatively high, its penetration in the skin is very problematic when topically applied, and HA-based creams, lotions and serums will only moisturize the superficial layers of the skin. On the contrary, when orally administered, 90% of the ingested HA is absorbed into the body and migrate into connective tissues, such as skin (6-8). HA will then increase water in the skin and stimulates collagen, HA and proteoglycan synthesis as demonstrated in several clinical studies (9-13).

As a result, HA will provide a durable and deep skin hydration with a plumping effect.

Why NMN supplementation ?

NMN (Nicotinamide Mononucleotide) is a naturally occurring molecule found in all living cells. It serves as a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), an essential coenzyme required for cellular energy, DNA repair, and metabolism.

By middle age, our NAD+ levels have plummeted to half that of our youth (14).Because dietary amounts are too small to significantly impact NAD+ levels, oral supplementation is crucial.

Taken orally, NMN is rapidly absorbed and converted by cells into NAD+ for immediate use (15). This increase of NAD+ levels will regulate cellular stress and DNA damage, providing a cellular repair.

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